Recombinant human HE4 protein

Human Epididymis Protein 4 (HE4) Is a secreted glycoprotein that serous and endometrioid ovarian carcinoma overexpress.


HE4 tumor marker was first identified in the epithelium of the distal epididymis and was initially predicted to be a protease inhibitor involved in sperm maturation. HE4 is overexpressed in 93 percent of serious, 100 percent of endometrioid epithelial ovarian cancers, and 50 percent of clear cell (not mucinous) ovarian carcinomas. HE4 is secreted into the circulation resulting in elevated serum levels. And if you may have interest, we also provide a tumor markers list.