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Progesterone (Prog)

Progesterone is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called progestogens and is the major progestogen in the body.


Progesterone levels vary during a woman's menstrual cycle. The classes start low, then increase after the ovaries release an egg.

If you become pregnant, progesterone levels will continue to rise as your body gets ready to support a developing baby. If you don't, your progesterone levels will decrease, and your period will begin.


Progesterone levels in a pregnant woman are about ten times higher than those who are not pregnant. In men, the adrenal glands and testes generate progesterone. Men also make progesterone but in much smaller amounts.


The performance data of the Prog rapid Quantitative Test Kit (FIA)

Manufacturer

SEKBIO

Parameter

Progesterone (PROG) Rapid Quantitative Test Kit (FIA)

Linearity

0.5ng/mL~60ng/mL

Detection limit

0.5ng/mL

Benchmark product

Roche


1 Limit of detection

Result(C/T)

Concentration

0

0.46

1

0.26445

0.50156

2

0.28688

0.43836

3

0.24489

0.51137

4

0.31987

0.42028

5

0.26411

0.44128

6

0.30127

0.42296

7

0.24441

0.52822

8

0.28998

0.44220

9

0.26857

0.44857

10

0.31376

0.48088

11

0.28120

0.41962

12

0.31124

0.52393

13

0.28228

0.44837

14

0.26100

0.39458

15

0.25996

0.51431

16

0.26714

0.43638

17

0.24321

0.46949

18

0.29104

0.51076

19

0.27968

0.41396

20

0.28350

0.50192

AVE

0.27792

0.46345

SD

0.02267

/

AVE+2*SD

0.32326

/

regression equation

y=0.40332x+0.27792

LoB(ng/mL)

0.11242


2 Linear

Cal

Concentration

Result

AVERAGE

S1

0.46

0.42

0.46

0.50

0.45

S2

1.78

1.57

1.67

1.75

1.69

S3

3.34

3.05

3.40

3.51

3.65

S4

10.76

11.75

10.68

9.35

10.94

S5

30.27

36.27

32.26

27.57

32.94

S6

62.32

58.23

60.26

65.90

56.64


5.jpg


3 Accuracy

Cal

concentration

Result

Bias

A1

1.78

1.62

-8.8%

1.95

9.6%

1.86

4.4%

A2

15.76

15.63

-0.9%

15.84

0.5%

16.48

4.6%

A3

30.27

29.29

-3.2%

28.57

-5.6%

33.17

9.6%


4 Precision

Cal

Concentration

Cal

Concentration

Cal

Concentration

R1

1.56

R2

16.33

R3

32.81

1.95

13.56

32.30

1.98

13.66

27.37

1.57

14.60

25.93

1.61

16.04

26.77

1.76

13.74

28.49

1.53

14.23

30.94

1.94

14.16

30.32

1.86

16.55

34.04

1.88

18.05

31.55

AVE

1.77

AVE

15.09

AVE

30.05

SD

0.18

SD

1.54

SD

2.77

CV

10.2%

CV

10.2%

CV

9.2%



5 Method Comparison

6.jpg



Sample

Roche

Sekbio

Sample

Roche

Sekbio

1

30.05

30.61

31

24.17

28.12

2

32.94

36.47

32

7.81

8.30

3

8.42

9.80

33

2.67

2.69

4

48.82

46.01

34

43.60

39.92

5

3.11

2.93

35

27.86

30.83

6

2.18

2.13

36

1.70

1.64

7

0.67

0.73

37

4.77

5.82

8

2.44

2.21

38

2.40

2.21

9

3.31

3.42

39

2.25

2.62

10

10.62

9.38

40

2.68

2.94

11

2.07

2.25

41

5.13

4.81

12

3.62

3.11

42

9.16

11.13

13

4.49

4.67

43

1.09

1.12

14

1.12

0.99

44

44.24

39.55

15

27.63

26.30

45

26.76

27.91

16

24.69

27.58

46

2.33

2.61

17

46.55

43.83

47

1.73

2.15

18

22.46

19.65

48

26.37

26.49

19

7.31

7.23

49

2.23

2.39

20

0.52

0.56

50

1.37

1.39

21

6.75

5.41

51

3.05

3.00

22

20.93

21.28

52

57.55

54.59

23

5.18

5.69

53

2.74

2.81

24

2.44

2.64

54

2.60

2.88

25

1.62

1.58

55

35.71

29.40

26

13.14

14.46

56

7.62

7.40

27

10.40

11.68

57

1.46

1.45

28

17.09

15.14

58

2.06

2.16

29

1.24

1.18

59

1.49

1.41

30

8.75

8.87

60

17.05

18.12


Progesterone (Prog) Products

AntibodyApplication
Mouse Anti-human Prog mAb

For immunodiagnostic: ELISA, LFA, CLIA


Progesterone Intro

Progesterone is the main biologically active progesterone secreted by the ovary, and its molecular formula is C21H30O2. Before ovulation, the amount of progesterone hormone produced per day is 2 to 3 mg, mainly from the ovaries.


Progesterone can protect the endometrium of women. After ovulation, it rises to 20~30mg per day, most of which is secreted by the corpus luteum in the ovary. During pregnancy, progesterone hormones can provide support and protection for the early growth and development of the fetus and can play a specific role in calming the uterus. In addition, the relationship between progesterone and estrogen is inseparable, both of which are vital female hormones. The role of estrogen is mainly to promote the development and maturity of female secondary sexual characteristics. In contrast, progesterone further promotes the growth and maturity of secondary sexual characteristics based on the role of estrogen, and there is a synergistic effect between the two

Estrogen and Progesterone

Estrogen, also known as the female hormone, is a primarily female hormone. It promotes the maturation of female genital organs and the appearance of secondary sexual characteristics and maintains normal libido and reproductive function hormones. There are two main groups (both steroid hormones), estrogen and progesterone.


Estrogen is secreted by the follicular cells of the ovary (the placenta also secretes estrogen), mainly estradiol and inactivated in the liver, converted to estriol and estrone, and combined with glucuronic acid and excreted in the urine. During pregnancy, the placenta secretes large amounts of estriol.


Estrogen is the sex hormone of female vertebrates and promotes the appearance of secondary sexual characteristics. Mammals can also make the filtrate after ovulation into the corpus luteum. They can secrete progesterone (also known as progesterone hormone, progesterone) called the second estrogen, which can control pregnancy lactation, and further promote secondary sexual characteristics mature function.

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