Pepsinogens I (PGI)

Pepsinogens (PG) originating from gastric mucosa can classify into two immunochemically distinct groups: pepsinogen I (PG I) and PG II, which mainly secrete into the gastric lumen, and nearly 1% of them leak into the blood circulation.

Serum PG levels reflect the morphological and functional status of the gastric mucosa. The serum or plasma PGI (P-PGI, S-PGI) assay is reliable for detecting patients with advanced atrophic corpus gastritis.

And serum PG tests served as a valuable marker for gastric cancer (GC) prevalence in a cross-sectional setting.

At present, the commonly used methods for PG detection are radioimmunoassay (RIA), ELISA, chemiluminescence (CLIA), time-resolved fluorescence immunoassay (FIA), and latex-enhanced immunoturbidimetric assay.

Pepsinogens I (PGI) Products

Antibody	Application
Anti-human PGI monoclonal antibody	For immunodiagnostic: ELISA, LFA, CLIA

Antigen	Application
PGI antigen	For immunodiagnostic: ELISA, LFA, CLIA

Pepsinogen I Intro

PGI is an indicator for detecting the function of oxyntic gland cells. Increased gastric acid secretion increases PGI, while secretion decreases or gastric mucosa gland atrophy decreases PGI; PGII has a more significant correlation with gastric fundus mucosal lesions (relative to gastric antrum mucosa), and its increase Higher levels were associated with atrophy of gastric fundus ducts, gastric epithelial metaplasia or pseudopyloric gland metaplasia, and atypia. The progressive decrease in PGI/II ratio was related to the progression of gastric mucosal atrophy. Therefore, the combined PGI and PGII ratio can play the "serological biopsy" of gastric fundic gland mucosa.

Pepsinogen I Antibody

Pepsinogen is synthesized by the chief cells of oxyntic glands and is converted into pepsin by hydrochloric acid (HCL) or active pepsin in the gastric cavity and decomposes proteins into fat peptone and a small amount of polypeptide. After entering the small intestine, the enzyme activity is lost. The optimum pH for the action of this enzyme is 2.

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