Placental Growth Factor (PLGF)

PLGF is a protein with an autocrine effect on trophoblast cell functions and a paracrine effect on vascular growth. PLGF is a member of the vascular endothelial growth factor (VEGF) family, and its molecular structure is a glycoprotein homodimer molecule.

Syncytiotrophoblast cells mainly synthesized PlGF and bound to tyrosinase receptors located in trophoblast cells and vascular endothelial cells.

The placental growth factor plays a unique role in regulating the functions of trophoblast cells and endothelial cells and can promote angiogenesis. Detection of serum placental growth factor levels in pregnant women can identify the oxygen supply pressure of placental syncytiotrophoblast cells, predict, identify and treat preeclampsia.

Placental Growth Factor (PLGF Antibody) Product

Antibody	Application
Mouse Anti-human PlGF mAb	For immunodiagnostic: ELISA, LFA, CLIA
Humanized Anti-human PlGF mAb	For immunodiagnostic: ELISA, LFA, CLIA

PLGF Intro

Placental growth factor has a unique regulatory effect on trophoblast and endothelial cells' function and can promote angiogenesis. The placental growth factor was first isolated and purified from the human placental cDNA library in 1991 by Maglione et al. It is mainly synthesized by syncytiotrophoblast cells and binds to tyrosinase receptors in trophoblast cells and vascular endothelial cells. It is a protein with autocrine effects on trophoblast cell function and paracrine effects on vascular growth. Detection of placental growth factor levels in pregnant women's blood can be used clinically to identify the oxygen supply pressure of placental syncytiotrophoblast cells and predict, identify, and monitor preeclampsia.

PLGF Test

The placental growth factor is a highly specific marker. PLGF levels are significantly reduced when placental syncytiotrophoblast cells are under oxygen stress. Quidel Triage PLGF can be used to assess placental insufficiency and predict the resulting preeclampsia, identification, and treatment monitoring.

1. Changes in blood PLGF levels in normal pregnancy

2. PLGF can be used to evaluate placental syncytiotrophoblastic disease and its complications

3. Predicting Preeclampsia

4. Identifying and distinguishing the placental origin of preeclampsia

5. Take reasonable steps to reduce the risk of preeclampsia

6. Risk stratification and surveillance for preeclampsia

7. Identifying intrauterine growth restriction

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