Mx gene was found in 1964 and was named after its resistance to #myxovirus.


After the viral infection, the Mx gene is induced by type I interferon-#IFN (α/β) to produce #MxA and #MxB proteins, which are distributed in the cytoplasm.

Mx proteins are interferon-induced GTPases and central players of the innate immune system. They mediate cellular resistance against various pathogens, including influenza and many other viruses.

MxA protein acts on the viral capsid and can inhibit viral transcription and translation. It is closely related to viral #infection, and a small amount or even a small amount of virus can induce cell expression, which can be used for early diagnosis of viral infection.

Due to its high sensitivity and specificity to viruses, MxA and #CRP can be tested simultaneously to identify clinically underlying febrile acute respiratory infections (ARI) and aid in identifying viral and bacterial infections.

(MxA-,CRP+): Consider bacterial infection and #antibiotics.

(MxA+,CRP+/-): Consider viral infection.

(MxA-,CRP-): Consider other infection and #inflammatory markers tests.