Gentamicin, Lincomycin, Erythromycin, Tylosin, Monensin & Ivermectin Antibodies for Food Safety ELISA & LFA IVD Development
Macrolide and polyether antibiotic residue antibodies are monoclonal antibodies raised against veterinary antibiotic and antiparasitic drug haptens conjugated to carrier proteins (BSA), used in competitive ELISA and lateral flow (LFA) immunoassays to detect drug residues in food, feed, and animal-derived products at parts-per-billion sensitivity. This product group spans several structurally distinct but commercially related drug classes that are frequently screened together in veterinary residue monitoring programs: aminoglycosides (gentamicin, spectinomycin), lincosamides (lincomycin), true macrolides (erythromycin, tylosin, tilmicosin), ionophore coccidiostats (monensin), and avermectin antiparasitics (abamectin, ivermectin). Because free drug residue in a sample competes with a drug-BSA conjugate for a fixed quantity of antibody in the competitive format, high residue concentration produces a weak or absent signal — enabling rapid, field-deployable screening without laboratory-grade chromatography instrumentation.
These compounds serve distinct but related roles in livestock and poultry production. Gentamicin and spectinomycin are aminoglycoside antibiotics used to treat bacterial infections in food-producing animals. Lincomycin is a lincosamide antibiotic commonly used in swine and poultry, closely related in structure and antibacterial spectrum to clindamycin. Erythromycin, tylosin, and tilmicosin are macrolide antibiotics used across livestock, poultry, and aquaculture for both disease treatment and, historically, growth promotion. Monensin is an ionophore coccidiostat — a feed additive used specifically in poultry and cattle production to control coccidiosis, a common and economically significant parasitic disease. Abamectin and ivermectin are avermectin-class antiparasitic agents used to control internal and external parasites in livestock. Residues of any of these compounds in meat, milk, or eggs are subject to maximum residue limit (MRL) regulation in major food-safety jurisdictions, making rapid, sensitive antibody-based screening essential for slaughterhouse, dairy, and export quality control programs.
Sekbio's panel covers all eight targets as monoclonal antibodies matched with BSA conjugates, uniformly priced at $895.52/mg. Gentamicin (IC50 0.1 ppb, ELISA sensitivity 0.05 ppb, LFA sensitivity 1–10 ppb) delivers the panel's most sensitive performance. Lincomycin (IC50 0.2 ppb, ELISA sensitivity 0.1 ppb, LFA sensitivity 2–10 ppb) cross-reacts with clindamycin at approximately 50%. Spectinomycin (IC50 0.2 ppb, ELISA sensitivity 0.2 ppb, LFA sensitivity 20 ppb) and Erythromycin (IC50 0.2 ppb, ELISA sensitivity 0.2 ppb, LFA sensitivity 10 ppb, cross-reactive with erythromycin thiocyanate and succinate) round out the antibacterial targets. The Tylosin/Tilmicosin 2-in-1 antibody (IC50 0.2 ppb, ELISA sensitivity 0.2 ppb, LFA sensitivity 30 ppb) provides combined macrolide detection. Abamectin (IC50 1 ppb, ELISA sensitivity 0.5 ppb), Monensin (IC50 0.5 ppb, ELISA sensitivity 1 ppb), and Ivermectin (IC50 0.5 ppb, ELISA sensitivity 5 ppb) complete the ionophore and avermectin coverage.
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Eight monoclonal antibodies covering aminoglycoside, lincosamide, macrolide, ionophore, and avermectin veterinary drug residues.
| Target | Class | IC50 | ELISA Sensitivity | LFA Sensitivity | Key Cross-reactivity | Price (mAb or Conjugate, 1mg) |
|---|---|---|---|---|---|---|
| Gentamicin | Aminoglycoside | 0.1 ppb | 0.05 ppb | 1–10 ppb | Class-specific | $895.52/mg |
| Lincomycin | Lincosamide | 0.2 ppb | 0.1 ppb | 2–10 ppb | Clindamycin ~50% | $895.52/mg |
| Spectinomycin | Aminoglycoside | 0.2 ppb | 0.2 ppb | 20 ppb | Class-specific | $895.52/mg |
| Erythromycin | Macrolide | 0.2 ppb | 0.2 ppb | 10 ppb | Erythromycin thiocyanate & succinate | $895.52/mg |
| Tylosin / Tilmicosin (2-in-1) | Macrolide | 0.2 ppb | 0.2 ppb | 30 ppb | Strong tylosin ↔ tilmicosin | $895.52/mg |
| Abamectin (Avermectin) | Avermectin | 1 ppb | 0.5 ppb | Contact us | Class-specific | $895.52/mg |
| Monensin | Ionophore | 0.5 ppb | 1 ppb | Contact us | Class-specific | $895.52/mg |
| Ivermectin | Avermectin | 0.5 ppb | 5 ppb | Contact us | Class-specific | $895.52/mg |
IC50 and sensitivity values from COA release testing in competitive ELISA format. Prices are reference list prices per 1 mg of monoclonal antibody or matching hapten-BSA conjugate; OEM bulk-scale pricing for 10 mg to gram quantities is quoted on request. Contact info@sekbio.com for full performance data and OEM supply pricing.
Sub-ppb-sensitivity antibodies validated across dairy, poultry feed, aquaculture, and meat export matrices for veterinary antibiotic and antiparasitic residue monitoring.
Sekbio's gentamicin antibody achieves IC50 of 0.1 ppb and ELISA sensitivity of 0.05 ppb — the most sensitive values in this eight-target panel — with colloidal-gold LFA sensitivity of 1–10 ppb. Gentamicin is one of the most widely used aminoglycoside antibiotics in veterinary medicine, making this antibody a natural anchor target for dairy and meat aminoglycoside residue screening panels.
Sekbio's lincomycin antibody (IC50 0.2 ppb, ELISA sensitivity 0.1 ppb) cross-reacts with clindamycin at approximately 50%, extending coverage across the lincosamide antibiotic class within a single reagent. This broader class detection is useful for swine and poultry residue panels where either lincosamide drug may be present.
Sekbio's erythromycin antibody (IC50 0.2 ppb, ELISA sensitivity 0.2 ppb, LFA sensitivity 10 ppb) is cross-reactive with erythromycin thiocyanate and erythromycin succinate — the two most common erythromycin salt/ester forms used in veterinary formulations. This ensures reliable detection regardless of which erythromycin derivative was administered.
Sekbio's tylosin monoclonal antibody is engineered with strong cross-reactivity to tilmicosin (IC50 0.2 ppb, ELISA sensitivity 0.2 ppb, LFA sensitivity 30 ppb), functioning as a combined detection reagent for both widely used macrolide antibiotics. This reduces the number of separate reagents a kit manufacturer needs to validate for macrolide residue screening in livestock and poultry.
Sekbio's monensin antibody (IC50 0.5 ppb, ELISA sensitivity 1 ppb) targets this widely used poultry and cattle coccidiostat, while abamectin (IC50 1 ppb, ELISA sensitivity 0.5 ppb) and ivermectin (IC50 0.5 ppb, ELISA sensitivity 5 ppb) antibodies cover the avermectin antiparasitic class. Together these three reagents extend Sekbio's veterinary drug residue panel beyond antibacterial compounds into feed additive and antiparasitic residue monitoring.
MOQ 1 mg per antibody for R&D evaluation. OEM quantities from 10 mg to gram scale available for food safety kit manufacturing. Sekbio's ISO 13485-certified Shenzhen facility provides quality-assured antibody production with lot COA documentation, serving dairy processors, poultry feed manufacturers, aquaculture producers, and meat export quality control laboratories. For broader veterinary drug residue coverage, see our antibiotic residue antibodies and aminoglycoside residue antibodies, or explore the full antibody catalog.
Sub-ppb competitive immunoassay antibodies for dairy, poultry feed, aquaculture, and meat export veterinary drug residue screening.
Raw milk and dairy processing quality control programs routinely screen for both macrolide antibiotics (erythromycin) and aminoglycosides (gentamicin), since these antibiotic classes are commonly used to treat mastitis and other bacterial infections in dairy cattle. Sekbio's gentamicin and erythromycin antibodies support ELISA and LFA screening panels for farm-gate and processing-plant milk testing.
Monensin, an ionophore coccidiostat, is a common feed additive in poultry and cattle production used to control coccidiosis. Feed manufacturers and poultry producers use Sekbio's monensin antibody to verify feed formulation compliance and monitor for potential carryover contamination between medicated and non-medicated feed production lines.
Erythromycin and lincomycin are used in aquaculture for bacterial disease treatment in farmed fish and shrimp, making residue screening in aquaculture products a standard export compliance requirement, particularly for shipments destined for the EU and US markets. Sekbio's erythromycin and lincomycin antibodies support rapid on-site or laboratory screening for aquaculture producers and exporters.
Meat exporters serving markets with strict veterinary drug residue limits rely on comprehensive antibody panels spanning multiple drug classes — including the aminoglycosides, macrolides, ionophores, and avermectins covered on this page — to verify shipment compliance before export. Sekbio's eight-target panel enables exporters to build multi-analyte screening programs covering this broad and commercially important residue category. Contact our team for export-matrix extraction protocols.
Technical and commercial questions from food safety IVD developers and kit manufacturers building macrolide and polyether antibiotic residue screening assays.
This panel covers a broad group of veterinary antibiotics and antiparasitic agents widely used across livestock, poultry, and aquaculture for disease treatment and, historically, growth promotion: Aminoglycosides (gentamicin, spectinomycin), used to treat bacterial infections in livestock and poultry; Lincosamides (lincomycin), commonly used in swine and poultry, with notable cross-reactivity to clindamycin; Macrolides (erythromycin, tylosin, tilmicosin), broad-spectrum antibiotics used across livestock, poultry, and aquaculture; Ionophores (monensin), a coccidiostat class used as a feed additive in poultry and cattle to control coccidiosis; and Avermectins (abamectin, ivermectin), antiparasitic agents used to control internal and external parasites in livestock. All eight antibodies are monoclonal and matched with BSA hapten conjugates for competitive ELISA and LFA assay development.
Yes — Sekbio's lincomycin monoclonal antibody (IC50 0.2 ppb) shows approximately 50% cross-reactivity with clindamycin. This is generally treated as a useful feature rather than a limitation, since lincomycin and clindamycin are both lincosamide-class antibiotics with related veterinary and human medical uses, and screening panels often benefit from broader lincosamide-class coverage in a single assay. Laboratories requiring lincomycin-specific quantification without clindamycin interference should confirm current cross-reactivity data with Sekbio and consider confirmatory chromatographic testing (LC-MS/MS) for definitive compound identification.
Sekbio's Tylosin/Tilmicosin antibody is a tylosin monoclonal antibody engineered with strong cross-reactivity to tilmicosin, effectively functioning as a 2-in-1 reagent for both macrolide antibiotics (IC50 0.2 ppb, ELISA sensitivity 0.2 ppb, colloidal-gold LFA sensitivity 30 ppb). Tylosin and tilmicosin are both widely used macrolide antibiotics in livestock and poultry production, and are frequently screened together in veterinary drug residue monitoring programs. A single antibody covering both compounds simplifies kit design and reduces the number of separate reagents a manufacturer needs to stock and validate.
Ionophores, represented here by monensin (IC50 0.5 ppb, ELISA sensitivity 1 ppb), are a class of coccidiostat compounds used as feed additives in poultry and cattle production to control coccidiosis, a common parasitic disease. Avermectins, represented here by abamectin (IC50 1 ppb, ELISA sensitivity 0.5 ppb) and ivermectin (IC50 0.5 ppb, ELISA sensitivity 5 ppb), are antiparasitic agents used to control internal and external parasites in livestock. These compounds are grouped alongside macrolide antibiotics on this page because they are frequently screened together as part of comprehensive veterinary drug residue monitoring programs for feed and meat products, even though they are structurally and pharmacologically distinct from true macrolides.
Sekbio's macrolide and polyether antibiotic residue antibodies are validated for competitive ELISA and LFA testing across matrices relevant to each target: Dairy and milk, for combined macrolide and aminoglycoside residue screening (gentamicin, erythromycin); Poultry feed, for ionophore coccidiostat monitoring (monensin) and macrolide residue screening (tylosin/tilmicosin); Aquaculture products, for macrolide and lincosamide screening (erythromycin, lincomycin); and Meat export quality control, where importing countries enforce residue limits across this broad antibiotic and antiparasitic drug group. Contact info@sekbio.com for matrix-specific extraction protocols.
All eight antibodies on this page — gentamicin, lincomycin, spectinomycin, erythromycin, tylosin/tilmicosin, abamectin, monensin, and ivermectin — are priced at $895.52 per mg, covering either the monoclonal antibody or its matching hapten-BSA conjugate (1 mg each). MOQ is 1 mg per reagent for R&D evaluation; OEM bulk-scale pricing for 10 mg to gram quantities is quoted on request. Contact info@sekbio.com for a formal quotation and current lead times.
Gentamicin has the strongest documented performance in this panel: IC50 of 0.1 ppb and ELISA sensitivity of 0.05 ppb, the lowest (most sensitive) values among all eight targets, with colloidal-gold LFA sensitivity of 1–10 ppb. Gentamicin is also one of the most widely recognized and widely used aminoglycoside antibiotics in veterinary medicine, making it a common anchor target for dairy and meat residue screening panels alongside the other macrolide-class antibiotics on this page.
Request macrolide and polyether antibiotic residue antibody evaluation kits, hapten conjugates, or discuss OEM food safety ELISA and LFA kit development support.