MQCA (Olaquindox Metabolite), Ribavirin & Amantadine Antibodies for Food Safety ELISA & LFA IVD Development
Antiviral drug residue antibodies are monoclonal or polyclonal antibodies raised against antiviral and antimicrobial growth-promoter drug haptens conjugated to carrier proteins (BSA), used to detect residues of these compounds in animal-derived food, feed, and related matrices via competitive immunoassay. Unlike the broad antibiotic classes used therapeutically in livestock, the three targets on this page — MQCA (the marker metabolite of olaquindox), ribavirin, and amantadine — share a common regulatory theme: each represents a compound where any detectable residue is a clear-cut violation, either because the parent compound is an outright banned growth promoter, or because the drug has no approved veterinary use in food animals at all. Competitive ELISA and lateral flow (LFA) formats — where free drug residue in a sample competes with a drug-BSA conjugate for antibody binding — provide the ppb-level sensitivity needed to detect these residues at the trace concentrations relevant to food safety enforcement.
Olaquindox is a banned quinoxaline-class antimicrobial growth promoter historically used in swine feed; because the parent olaquindox molecule degrades quickly in animal tissue, MQCA (methyl-3-quinoxaline-2-carboxylic acid) — its major stable metabolite — is the standard analytical marker used to detect historical olaquindox exposure, since it persists in tissue longer than the parent drug. Ribavirin is a broad-spectrum antiviral drug with established human medical uses but no approved veterinary use in any food-producing animal in China, the EU, or the United States — meaning any detected residue in meat, milk, eggs, or aquatic products is, by definition, evidence of illegal off-label use, most often documented during viral disease outbreaks in aquaculture and livestock. Amantadine is an antiviral drug with activity against influenza A viruses; it is banned for veterinary and agricultural use in poultry in both China and the United States because illegal use in flocks has been linked to the emergence of amantadine-resistant avian influenza strains, a resistance-driving effect that also threatens amantadine's usefulness as a human antiviral treatment during influenza outbreaks.
Sekbio's antiviral and antimicrobial growth-promoter residue antibody line covers all three targets. The MQCA/olaquindox metabolite monoclonal antibody and matching BSA conjugate achieve IC50 of 0.3 ppb, ELISA sensitivity of 0.2 ppb, and colloidal-gold LFA sensitivity of 1 ppb. The ribavirin antibody — a polyclonal antibody, not monoclonal — and matching BSA conjugate achieve IC50 of 0.3 ppb and ELISA sensitivity of 0.2–1 ppb. The amantadine monoclonal antibody and matching BSA conjugate achieve IC50 of 1.5 ppb and ELISA sensitivity of 1 ppb. All three reagents are priced at $895.52/mg, covering either the antibody or its matching hapten-BSA conjugate.
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Three reagents covering the major antiviral and antimicrobial growth-promoter compounds where any residue detection represents a zero-tolerance food safety violation.
| Target | Antibody Type | IC50 | ELISA Sensitivity | LFA Sensitivity | Price (mAb/pAb or Conjugate, 1mg) |
|---|---|---|---|---|---|
| MQCA (Olaquindox Metabolite) | Monoclonal | 0.3 ppb | 0.2 ppb | 1 ppb | $895.52/mg |
| Ribavirin | Polyclonal | 0.3 ppb | 0.2–1 ppb | Contact us | $895.52/mg |
| Amantadine | Monoclonal | 1.5 ppb | 1 ppb | Contact us | $895.52/mg |
IC50 and sensitivity values from COA release testing in competitive ELISA format. Prices are reference list prices per 1 mg of antibody or matching hapten-BSA conjugate; OEM bulk-scale pricing for 10 mg to gram quantities is quoted on request. Contact info@sekbio.com for full performance data and OEM supply pricing.
Sub-ppb-sensitivity antibodies for compounds with zero legal tolerance in food animals — banned growth promoters and antiviral drugs with no approved veterinary use.
Sekbio's MQCA monoclonal antibody achieves IC50 of 0.3 ppb, ELISA sensitivity of 0.2 ppb, and colloidal-gold LFA sensitivity of 1 ppb. Because olaquindox itself degrades quickly in animal tissue, MQCA is the analytically reliable marker used to detect historical olaquindox use — a banned quinoxaline-class antimicrobial growth promoter — in swine and swine feed. This antibody supports both ELISA laboratory testing and rapid LFA field screening for olaquindox compliance verification.
Sekbio's ribavirin polyclonal antibody (IC50 0.3 ppb, ELISA sensitivity 0.2–1 ppb) supports screening for a drug with no approved veterinary use in any food-producing animal. Any detectable ribavirin residue in meat, milk, eggs, or aquatic products is a clear regulatory violation, most commonly linked to illegal off-label antiviral use during disease outbreaks. This antibody is produced as a polyclonal reagent, distinct from the monoclonal MQCA and amantadine antibodies on this page.
Sekbio's amantadine monoclonal antibody (IC50 1.5 ppb, ELISA sensitivity 1 ppb) supports screening for a compound banned in poultry production in China and the United States due to its documented role in driving amantadine-resistant avian influenza virus strains. Beyond the direct food safety residue concern, amantadine screening protects the broader public health value of amantadine as a human antiviral treatment by discouraging agricultural misuse that accelerates drug resistance.
Each of the three antibodies on this page — MQCA, ribavirin, and amantadine — is supplied with a matching hapten-BSA conjugate, priced identically to the antibody itself at $895.52/mg. This gives ELISA and LFA kit developers everything needed to build a complete competitive assay: the drug-specific antibody plus the corresponding conjugate for plate coating or membrane striping.
This panel includes both antibody formats: monoclonal antibodies for MQCA and amantadine, and a polyclonal antibody for ribavirin. Kit developers benefit from having both formats validated and available from a single supplier, simplifying sourcing for multi-target antiviral residue test kits without needing to qualify separate vendors for monoclonal versus polyclonal reagents.
MOQ 1 mg per reagent for R&D evaluation. OEM quantities from 10 mg to gram scale available for food safety kit manufacturing. Sekbio's ISO 13485-certified Shenzhen facility provides quality-assured antiviral residue antibody production with lot COA documentation, serving poultry and swine feed manufacturers, aquaculture producers, and import/export testing laboratories. For broader veterinary drug residue coverage, see our antibiotic residue antibodies and macrolide antibiotic residue antibodies, or explore the full antibody catalog.
Zero-tolerance screening antibodies for banned antimicrobial growth promoters and antiviral drugs with no approved veterinary use in food-producing animals.
Amantadine residue screening in poultry meat and feed addresses both a direct food safety concern and a broader public health issue: illegal amantadine use in poultry flocks has been linked to the emergence of amantadine-resistant avian influenza strains, undermining the drug's usefulness as a human antiviral treatment. Sekbio's amantadine antibody supports poultry processors and feed manufacturers in verifying amantadine-free compliance across their supply chain, particularly during and after regional avian influenza outbreaks when illegal use pressure is historically highest.
Olaquindox was historically used as a swine feed growth promoter before being banned; because the parent compound degrades quickly, MQCA residue testing in swine feed and swine-derived food products is the reliable method for verifying historical compliance. Sekbio's MQCA antibody supports feed manufacturers and swine processors in confirming that banned olaquindox use has not occurred in their supply chain.
Ribavirin has no approved veterinary use in any food-producing animal, yet documented cases of illegal off-label antiviral use during viral disease outbreaks in aquaculture and livestock make ribavirin residue screening an important safeguard. Sekbio's ribavirin polyclonal antibody supports aquaculture producers and animal-derived food processors in verifying that no illegal antiviral treatment has occurred, particularly following regional disease outbreak events.
Countries importing meat, poultry, and aquaculture products enforce zero-tolerance policies for banned growth promoters and unapproved antiviral drugs, making antiviral residue screening a standard customs and border inspection checkpoint. Sekbio's MQCA, ribavirin, and amantadine antibodies support import/export compliance testing for meat processors, importers, and government inspection laboratories verifying shipments before goods clear customs. Contact our team for customs-matrix extraction protocols.
Technical and commercial questions from food safety IVD developers and kit manufacturers building antiviral residue screening assays.
MQCA (methyl-3-quinoxaline-2-carboxylic acid) is the primary stable metabolite of olaquindox, a quinoxaline-class antimicrobial growth promoter that was historically used in swine feed. Olaquindox itself degrades rapidly in animal tissue after administration, making the parent compound an unreliable and short-lived marker for residue testing. MQCA, by contrast, persists in tissue for a longer period after olaquindox exposure, making it the standard analytical marker used to detect historical olaquindox use — a testing approach analogous to detecting a banned drug through its longer-lived metabolite rather than the parent compound. Sekbio's MQCA monoclonal antibody and matching BSA conjugate achieve IC50 of 0.3 ppb, ELISA sensitivity of 0.2 ppb, and colloidal-gold LFA sensitivity of 1 ppb.
Ribavirin is a broad-spectrum antiviral drug approved for certain human medical uses (including hepatitis C and some viral hemorrhagic fevers) but has no approved veterinary use in food-producing animals in China, the EU, or the United States. Because there is no legal pathway for its presence in meat, milk, eggs, or aquatic products, any detectable ribavirin residue in an animal-derived food sample indicates illegal off-label use — most commonly during disease outbreaks, including avian influenza and other viral diseases in poultry and livestock, where producers may attempt to use human antiviral drugs without any approved dosing, withdrawal period, or safety data for food animals. Sekbio's ribavirin polyclonal antibody (note: polyclonal, not monoclonal) achieves IC50 of 0.3 ppb and ELISA sensitivity of 0.2–1 ppb for this zero-tolerance screening application.
Amantadine is an antiviral drug with activity against influenza A viruses, including avian influenza strains. It is banned for veterinary and agricultural use in poultry in China and the United States because widespread illegal use in flocks was linked to the emergence of amantadine-resistant avian influenza virus strains — resistance that can also compromise amantadine's effectiveness as a human antiviral treatment during influenza outbreaks. This dual concern (food safety residue risk plus drug-resistance-driven public health risk) makes amantadine residue testing a priority for poultry meat, eggs, and feed safety programs. Sekbio's amantadine monoclonal antibody achieves IC50 of 1.5 ppb and ELISA sensitivity of 1 ppb.
Sekbio's ribavirin antibody is polyclonal, not monoclonal — distinct from the MQCA and amantadine antibodies on this page, which are both monoclonal. Polyclonal antibodies are raised in whole animals and recognize multiple epitopes on the target hapten, which can offer robust binding affinity and is a well-established, widely used approach for small-molecule veterinary drug residue detection. The ribavirin polyclonal antibody (IC50 0.3 ppb, ELISA sensitivity 0.2–1 ppb) is fully compatible with standard competitive ELISA assay development; batch-to-batch epitope profile can vary slightly between polyclonal antibody lots compared to monoclonal antibodies, so lot-specific COA verification is recommended for kit manufacturers standardizing a long-term production run.
Sekbio's antiviral and antimicrobial growth-promoter residue antibodies are validated for the matrices most relevant to each target's historical use pattern: Poultry meat and feed for amantadine, reflecting its history of illegal use during avian influenza outbreaks and its link to drug-resistance concerns; Swine feed for olaquindox/MQCA, reflecting olaquindox's historical use as a swine growth promoter; Aquaculture and other animal-derived food for ribavirin, reflecting documented off-label antiviral use during viral disease outbreaks in aquaculture and livestock; and Import/export customs screening, where destination markets with zero-tolerance policies for these compounds require compliance verification before goods clear inspection. Contact info@sekbio.com for matrix-specific extraction protocols.
Reference pricing is $895.52 per mg for all three reagents on this page — MQCA/olaquindox metabolite monoclonal antibody (and matching BSA conjugate), ribavirin polyclonal antibody (and matching BSA conjugate), and amantadine monoclonal antibody (and matching BSA conjugate) — each price covering 1 mg of the antibody or its matching hapten-BSA conjugate. MOQ is 1 mg per reagent for R&D evaluation; OEM bulk-scale pricing for 10 mg to gram quantities is quoted on request. Contact info@sekbio.com for a formal quotation and current lead times.
The MQCA/olaquindox metabolite antibody is validated for both competitive ELISA (sensitivity 0.2 ppb) and colloidal-gold LFA (sensitivity 1 ppb) formats. The ribavirin polyclonal antibody is validated for competitive ELISA (sensitivity 0.2–1 ppb). The amantadine monoclonal antibody is validated for competitive ELISA (sensitivity 1 ppb). Contact info@sekbio.com to confirm current LFA validation status for ribavirin and amantadine, and for conjugation protocols and nitrocellulose membrane striping parameters for LFA kit development.
Request antiviral drug residue antibody evaluation kits, hapten conjugates, or discuss OEM food safety ELISA and LFA kit development support.