Ferritin Monoclonal Antibody for Iron Deficiency Anemia & Iron Status IVD Development
Ferritin is the primary intracellular iron storage protein found in virtually all living organisms. In humans, ferritin is a ~440–480 kDa hollow spherical complex assembled from 24 subunits of two types: the H-subunit (21 kDa, ferroxidase activity) and the L-subunit (19 kDa, nucleation activity). Each ferritin complex can store up to 4,500 iron atoms in a soluble, non-toxic ferric oxyhydroxide form, releasing them on demand for haemoglobin synthesis, enzyme function, and cellular metabolism.
Serum ferritin is the most clinically reliable indicator of total body iron stores and serves as the primary diagnostic biomarker for iron deficiency — the most common nutritional deficiency worldwide, affecting over 2 billion people and the leading cause of anaemia globally. Serum ferritin below 12 ng/mL confirms depleted iron stores (iron deficiency without anaemia); below 30 ng/mL in the context of elevated CRP indicates functional iron deficiency. Conversely, serum ferritin above 200 ng/mL (women) or 300 ng/mL (men) may indicate iron overload (haemochromatosis) or acute-phase response.
For IVD immunoassay development, ferritin quantification requires a matched antibody pair with non-overlapping epitope specificity. The ferritin 24-subunit shell provides multiple epitopes accessible to both capture and detection antibodies simultaneously. Sekbio supplies three ferritin antibodies (FERR-W022, FERR-W321, ZL26) validated for CLIA and LFA formats, covering the full clinical ferritin range from iron deficiency (<12 ng/mL) to iron overload (>1,000 ng/mL).
Three anti-Ferritin monoclonal antibodies for complete CLIA and LFA sandwich immunoassay development.
| Catalog No. | Product Name | Species | Purity | Intended Use | Storage |
|---|---|---|---|---|---|
| FERR-W022 | Mouse Anti-Ferritin Monoclonal Antibody | Mouse | >90% SEC-HPLC | Capture — CLIA, LFA | +2°C to +8°C |
| FERR-W321 | Mouse Anti-Ferritin Monoclonal Antibody | Mouse | >90% SEC-HPLC | Detection — CLIA, LFA | +2°C to +8°C |
| ZL26 | Anti-Ferritin Antibody (Complementary Clone) | Mouse | >90% SEC-HPLC | Detection / Capture — CLIA, LFA | +2°C to +8°C |
All products supplied in 20 mM PB, 150 mM NaCl, pH 7.4. MOQ 1 mg. OEM quantities (10 mg–gram scale) available. Contact info@sekbio.com for bulk pricing.
Engineered for the wide dynamic range and sensitivity required in clinical iron deficiency diagnosis, anaemia monitoring, and POCT.
Sekbio offers three anti-Ferritin antibodies (FERR-W022, FERR-W321, ZL26) targeting distinct epitopes on the ferritin 24-subunit shell. The multi-antibody panel enables developers to select the optimal capture/detection pair for their specific platform (CLIA or LFA) and required assay range (1–1,000 ng/mL).
All three antibodies are validated for both CLIA (high-sensitivity quantitative analyzer platforms) and LFA (lateral flow rapid test) formats. This enables a single raw material source for both hospital laboratory quantitative ferritin testing and community-level point-of-care iron status screening.
Antibody pair performance covers the clinically relevant ferritin range from <5 ng/mL (severe iron deficiency) to >1,000 ng/mL (iron overload/acute phase), supporting both paediatric iron deficiency screening and adult haemochromatosis monitoring applications in a single assay format.
Manufactured under ISO 13485 QMS with inter-batch CV <10%. Each lot undergoes appearance, purity by SEC-HPLC, and bioreactivity QC. Full Certificate of Analysis with every shipment. Consistent lot performance simplifies assay re-validation during OEM production scale-up.
Purity >90% by SEC-HPLC with aggregation <5% minimises non-specific binding in both CLIA microparticle assays and LFA nitrocellulose membranes. Lower background improves assay precision at the critical <12 ng/mL iron deficiency threshold, where accurate quantification is most important.
ISO 13485-compliant manufacturing in Shenzhen, China. MOQ 1 mg for R&D evaluation; gram-scale production supply for OEM kit manufacturing. Supports CE, NMPA, and FDA regulatory submissions. Ferritin POCT kits are in high demand in Africa, South Asia, and Southeast Asia for maternal and child health programmes.
Ferritin antibody pair validated for iron status assessment, anaemia diagnosis, and iron overload screening kit development.
Iron deficiency anaemia is the most prevalent nutritional disorder globally, affecting 1.62 billion people (WHO data). Serum ferritin <12 ng/mL is the WHO reference threshold for iron store depletion in children; <15 ng/mL in adults. Ferritin CLIA assays are the gold-standard test for iron deficiency in hospital laboratories, while ferritin lateral flow rapid tests support community-level screening in resource-limited settings. Sekbio's FERR-W022/FERR-W321 antibody pair supports both kit types.
Maternal iron deficiency during pregnancy is associated with preterm birth, low birth weight, and impaired foetal neurological development. WHO recommends serum ferritin as the primary biomarker for iron deficiency in pregnant women (<30 ng/mL with elevated CRP) and children aged 6–59 months (<12 ng/mL). Ferritin POCT rapid tests using Sekbio antibodies support field-deployable iron status assessment in antenatal care and child health programmes in Africa and South Asia.
Iron deficiency (functional and absolute) is common in chronic kidney disease (CKD) and heart failure (HFrEF/HFpEF), impairing haematopoiesis and exercise capacity. KDIGO guidelines recommend ferritin testing in all CKD patients receiving erythropoiesis-stimulating agents (ESA). ESC heart failure guidelines recommend intravenous iron supplementation when ferritin <100 ng/mL or <300 ng/mL with TSAT <20%. CLIA ferritin assays support ESA management and iron supplementation decision-making.
Ferritin lateral flow rapid tests are a priority product for IVD manufacturers serving the global health market. Rapid ferritin tests using Sekbio FERR-W022/FERR-W321/ZL26 antibodies can be formatted for whole blood or serum, with quantitative readout via fluorescence reader or semi-quantitative visual interpretation. OEM rapid test manufacturers can integrate Sekbio's antibody panel with ISO 13485-compliant batch data. Visit our Products page for complete raw material portfolio, or contact us.
Technical and commercial questions from IVD R&D engineers and procurement teams.
Ferritin is the body's primary iron storage protein — a 440–480 kDa complex of 24 subunits storing up to 4,500 iron atoms. Serum ferritin directly reflects total body iron stores and is more sensitive and specific for iron deficiency than serum iron or transferrin saturation. WHO recommends serum ferritin as the primary biomarker for iron deficiency: <12 ng/mL in children and <15 ng/mL in adults indicates depleted stores. Ferritin is also an acute-phase reactant, so CRP co-testing is recommended in inflammatory states.
Sekbio supplies: FERR-W022 (mouse anti-Ferritin mAb, capture antibody), FERR-W321 (mouse anti-Ferritin mAb, detection antibody), and ZL26 (complementary anti-Ferritin clone for alternative pairing). All are affinity-purified, purity >90% SEC-HPLC, supplied in 20 mM PB buffer. MOQ 1 mg; 3-year shelf life.
FERR-W022, FERR-W321, and ZL26 are validated for CLIA (chemiluminescence immunoassay) and LFA (lateral flow assay/rapid test) sandwich formats. The antibodies support both quantitative hospital laboratory CLIA analyzer platforms and point-of-care lateral flow strips for community iron screening — from a single antibody source.
The 24-subunit ferritin shell presents multiple epitope clusters. Offering three antibodies (FERR-W022, FERR-W321, ZL26) gives developers the flexibility to identify the optimal capture/detection pairing for their specific platform, buffer conditions, and assay range. Some pairs may offer superior sensitivity at <12 ng/mL for iron deficiency diagnosis; others may provide better linearity at >500 ng/mL for iron overload monitoring. Contact info@sekbio.com for pair optimisation guidance.
MOQ is 1 mg for R&D evaluation; OEM quantities from 10 mg to gram scale available. Storage: +2°C to +8°C short-term (≤1 month); −20°C long-term. Avoid repeated freeze/thaw cycles. All supplied in 20 mM PB, 150 mM NaCl, pH 7.4. Shelf life: 3 years from manufacturing date.
Yes. The Ferritin antibodies (FERR-W022/FERR-W321/ZL26) are suitable for colloidal gold or fluorescent microsphere conjugation for LFA formats including whole blood application with haematocrit filters. Ferritin POC rapid tests for iron screening in community health and maternal care are a priority product line. Contact info@sekbio.com for LFA development support and sample kits. Visit our Platforms page for conjugation services.
Request the full technical datasheet, antibody pair specifications, or discuss OEM supply with our team.